1401412-99-4Relevant academic research and scientific papers
A general method for the one-pot reductive functionalization of secondary amides
Huang, Pei-Qiang,Huang, Ying-Hong,Xiao, Kai-Jiong,Wang, Yu,Xia, Xiao-Er
, p. 2861 - 2868 (2015)
A one-pot reaction for the transformation of common secondary amides into amines with C-C bond formation is described. This method consists of in situ amide activation with Tf2O-partial reduction-addition of C-nucleophiles. The method is general in scope, which allows employing both hard nucleophiles (RMgX, RLi) and soft nucleophiles, as well as enolates. With the use of soft nucleophiles, the reaction proceeded with high chemoselectivity at a secondary amide in the presence of ester, cyano, nitro, and tertiary amide groups.
Direct transformation of secondary amides into secondary amines: Triflic anhydride activated reductive alkylation
Xiao, Kai-Jiong,Wang, Ai-E,Huang, Pei-Qiang
supporting information; experimental part, p. 8314 - 8317 (2012/09/08)
Versatile and mild: The first general method for the title transformation has been developed (see scheme; 2-F-Py=2-fluoropyridine; Tf=trifluorosulfonyl). The amines are synthesized in good yields and the ketimine intermediates can be isolated before the r
