1401424-96-1

Upstream product

• 5396-89-4 benzyl acetoacetate 
• 3959-05-5 2-bromobenzylamine 
• 52267-50-2 benzyl-α-diazo-acetoacetate 
• 100-46-9 benzylamine 

Downstream Products

• 1401424-81-4 benzyl 3-methyl-1,2,3,4-tetrahydroisoquinoline-4-carboxylate 

Relevant academic research and scientific papers

Rhodium-Catalyzed Annulation of Primary Benzylamine with α-Diazo Ketone toward Isoquinoline

Rhodium-catalyzed annulation of commercially available primary benzylamine with α-diazo ketone was developed, leading to isoquinolines in moderate to good yields. This procedure features the employment of primary benzylamine as starting material as well as high selectivity in the 3- and 4- position of isoquinoline, generating a key compliment to the previously developed annulation with internal alkyne.

Enantioselective iridium-catalyzed hydrogenation of 3,4-disubstituted isoquinolines

Reining in the outliers: An efficient approach for enantioselective hydrogenation of 3,4-disubstituted isoquinolines was successfully developed. When isoquinolines are treated with [Ir(cod)Cl]2/(R)-synphos in the presence of 1-bromo-3-chloro-5,