1401460-42-1

Basic information

• Product Name: C₂₈H₂₉N₅O₂
• CAS NO: 1401460-42-1
• Molecular Weight: 467.571
• Mol File: 1401460-42-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₂₉N₅O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₂₉N₅O₂(1401460-42-1)
• EPA Substance Registry System: C₂₈H₂₉N₅O₂(1401460-42-1)

Safety Data

• Hazardous Substances Data: 1401460-42-1(Hazardous Substances Data)

Upstream product

• 1240521-70-3 (R)-1-fluoro-1-oxo-3-phenylpropan-2-yl acetate 
• 146235-25-8 (2R)-2-acetoxy-3-phenylpropanoic acid 
• 884495-39-0 5-bromo-2-(methyloxy)-3-pyridinamine 
• 1240521-73-6 (R)-1-(2-methoxy-5-(pyridine-4-yl)pyridine-3-ylamino)-1-oxo-3-phenylpropan-2-yl 4-nitrobenzenesulfonate 
• 52568-28-2 2-(pyridin-2-yl)isopropyl amine 
• 1240521-72-5 (R)-2-hydroxy-N-(6-methoxy-[3,4′-bipyridin]-5-yl)-3-phenylpropanamide 

Downstream Products

• 1401460-32-9 C₂₇H₂₇N₅O₂ 

Relevant articles and documents

Phenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes

GPR142 is a novel GPCR that is predominantly expressed in pancreatic β-cells. GPR142 agonists potentiate glucose-dependent insulin secretion, and therefore can reduce the risk of hypoglycemia. Optimization of our lead pyridinone-phenylalanine series led to a proof-of-concept compound 22, which showed in vivo efficacy in mice with dose-dependent increase in insulin secretion and a decrease in glucose levels.