1401464-30-9Relevant academic research and scientific papers
Synthesis, characterization, and X-ray structures of 2-(3,5 - Dimethylpyrazol-1-yl)phenyl-based organoselenium compounds and their glutathione peroxidase (GP X) like activity
Hodage, Ananda S.,Phadnis, Prasad P.,Wadawale, Amey,Jain, Vimal K.,Priyadarsini, K. I.
, p. 1419 - 1433,15 (2012)
The synthesis of a series of 2-(3,5-dimethylpyrazol-1-yl)phenyl-based organoselenium compounds, (dmpzC6H4Se)2 (1), dmpzC6H4SeR (dmpz = 3,5-dimethylpyrazol-1-yl; R = (CH2)nY; Y = OH, NH2, and COOH), and dmpzC6H4SeX (X = Cl, Br, or I) is described. The comp
Synthesis, characterization, structures and cytotoxicity of platinum(II) complexes containing dimethylpyrazole based selenium ligands
Chopade, Suresh M.,Phadnis, Prasad P.,Hodage, Ananda S.,Wadawale, Amey,Jain, Vimal K.
supporting information, p. 72 - 80 (2015/02/19)
A series of water soluble platinum(II) complexes of general formulae [Pt(en)(L)][NO3]2, [Pt(NH3)2(L)][NO3]2 [en = ethylenediamine; L = dmpzC6H4Se(CH2)nCOOH or dmpzCH2CH2Se(CH2)nCOOH (n = 1 and 2)], [Pt(en)(L)][NO3][OH]·H2O [L = dmpzCH2CH2Se(CH2)nCOOH (n = 1 and 2)] and [Pt(dmpzCH2CH2SeCH2CH2COOH)2][Cl]2·2H2O have been synthesized. They were characterized by microanalyses, IR, NMR (1H, 13C{1H}, 77Se{1H} and 195Pt{1H}) spectroscopy. Molecular structures of [Pt(en)(dmpzCH2CH2SeCH2COOH)][NO3][OH]·H2O and [Pt(dmpzCH2CH2SeCH2CH2COOH)2][Cl]2·2H2O were determined unambiguously by single crystal X-ray diffraction analyses. The cytotoxicity of these complexes has been evaluated against human colon (HT29, Colo205), ovarian (A2780) and bladder (T24) cancer cell lines and compared with the activity of cisplatin and adriamycin.
