1401533-12-7

Basic information

• Product Name: C₂₆H₂₈BrClN₂O₃S
• CAS NO: 1401533-12-7
• Molecular Weight: 563.943
• Mol File: 1401533-12-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₂₈BrClN₂O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₂₈BrClN₂O₃S(1401533-12-7)
• EPA Substance Registry System: C₂₆H₂₈BrClN₂O₃S(1401533-12-7)

Safety Data

• Hazardous Substances Data: 1401533-12-7(Hazardous Substances Data)

Upstream product

• 13035-19-3 4-aminopiperidine 
• 1029643-92-2 N-phenylmethylidenepiperidinyl-4-amine 
• 1044183-50-7 4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 3132-99-8 m-bromobenzoic aldehyde 
• 21815-91-8 3-chlorobenzo[b]thiophen-2-carbonyl chloride 
• 359877-98-8 tert-butyl 4-((3-bromophenyl)methyl)aminopiperidine carboxylate 

Downstream Products

• 1401532-94-2 C₂₁H₂₀BrClN₂OS 

Relevant articles and documents

Potent small molecule Hedgehog agonists induce VEGF expression in vitro

Here, we describe the synthesis, SAR studies as well as biological investigations of the known Hedgehog signaling agonist SAG and a small library of its analogues. The SAG and its derivatives were analyzed for their potency to activate the expression of the Hh target gene Gli1 in a reporter gene assay. By analyzing SAR important molecular descriptors for Gli1 activation have been identified. SAG as well as compound 10c proven to be potent activators of VEGF expression in cultivated dermal fibroblasts. Importantly and in contrast to SAG, derivative 10c displayed no toxicity in concentrations up to 250 μm.