1401533-17-2

Upstream product

• 13035-19-3 4-aminopiperidine 
• 1029643-92-2 N-phenylmethylidenepiperidinyl-4-amine 
• 1044183-50-7 4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 105-07-7 4-cyanobenzaldehyde 
• 21815-91-8 3-chlorobenzo[b]thiophen-2-carbonyl chloride 
• 888944-30-7 tert-butyl 4-((4-cyanobenzyl)amino)piperidine-1-carboxylate 

Downstream Products

• 1401532-99-7 C₂₂H₂₀ClN₃OS 

Relevant academic research and scientific papers

Potent small molecule Hedgehog agonists induce VEGF expression in vitro

Here, we describe the synthesis, SAR studies as well as biological investigations of the known Hedgehog signaling agonist SAG and a small library of its analogues. The SAG and its derivatives were analyzed for their potency to activate the expression of the Hh target gene Gli1 in a reporter gene assay. By analyzing SAR important molecular descriptors for Gli1 activation have been identified. SAG as well as compound 10c proven to be potent activators of VEGF expression in cultivated dermal fibroblasts. Importantly and in contrast to SAG, derivative 10c displayed no toxicity in concentrations up to 250 μm.