140157-10-4Relevant academic research and scientific papers
A one-pot generation of α-chloro-α-lithio alkanephosphonates. A new preparative route to 1,2-epoxyalkanephosphonates
Lee,Shin,Oh
, p. 649 - 655 (2007/10/02)
Reaction of lithio anion derived from diethyl alkanephosphonate in the presence of 2 eq. of n-BuLi with benzenesulfonyl chloride gives directly the corresponding diethyl-1-chloro-1-lithioalkanephosphonate, which reacts in situ with carbonyl compounds followed by intramolecular substitution reaction to give 1,2-epoxyalkanephosphonates.
