1401606-57-2

Upstream product

• 148218-48-8 ((4R,5S)-2,2-dimethyl-5-(prop-2-yn-1-yl)-1,3-dioxolan-4-yl)methanol 
• 19722-76-0 methyl-2,6-dihydroxy-4-methoxybenzoate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 86795-44-0 3,4-O-isopropylidene-2-deoxy-D-ribose 
• 83-30-7 acide 2,4,6-trihydroxybenzoique 
• 1401606-56-1 methyl 2-(3-((4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)prop-1-yn-1-yl)-6-(ethoxymethoxy)-4-methoxybenzoate 

Relevant academic research and scientific papers

Total synthesis of 7′,8′-dihydroaigialospirol

A highly convergent total synthesis of 7′,8′- dihydroaigialospirol is described. Key steps of the synthesis include a Nozaki-Hiyama-Kishi (NHK) coupling of an iodoalkyne with an advanced phthalide-aldehyde and a remarkable one-pot acid-mediated global deprotection/spiroacetalization.