1401619-01-9

Upstream product

• 199604-34-7 ethyl 1-(4-chlorobenzyl)-1H-indole-2-carboxylate 
• 3770-50-1 2-carbethoxyindole 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 220677-67-8 1-(4-chlorobenzyl)-1H-indole-2-carboxylic Acid 
• 1006-64-0 2-(phenyl)pyrrolidine 
• 1369487-49-9 1-(1-(4-chlorobenzyl)-1H-indole-2-carbonyl)piperidine-4-carboxylic acid 
• 1126-09-6 4-carbethoxypiperidine 
• 1369487-48-8 ethyl 1-(1-(4-chlorobenzyl)-1H-indole-2-carbonyl)piperidine-4-carboxylate 

Relevant academic research and scientific papers

Synthesis and biological activity of conformationally restricted indole-based inhibitors of neurotropic alphavirus replication: Generation of a three-dimensional pharmacophore

We have previously reported the development of indole-based CNS-active antivirals for the treatment of neurotropic alphavirus infection, but further optimization is impeded by a lack of knowledge of the molecular target and binding site. Herein we describe the design, synthesis and evaluation of a series of conformationally restricted analogues with the dual objectives of improving potency/selectivity and identifying the most bioactive conformation. Although this campaign was only modestly successful at improving potency, the sharply defined SAR of the rigid analogs enabled the definition of a three-dimensional pharmacophore, which we believe will be of value in further analog design and virtual screening for alternative antiviral leads.

ARBOVIRUS INHIBITORS AND USES THEREOF

The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides compounds as inhibitors of arboviruses.