1401686-08-5Relevant academic research and scientific papers
An efficient synthesis of D-galactose-based multivalent neoglycoconjugates
De Andrade, Saulo F.,Figueiredo, Rute C.,De Souza Filho, Jose? D.,Alves, Ricardo J.
, p. 1062 - 1069 (2012/09/10)
In this work, the synthesis of dimeric, trimeric and tetrameric D-galactose-based neoglycoconjugates is reported. The monosaccharide ligand was prepared in 5 straightforward steps from D-galactose using the Doebner modification of the Knoevenagel reaction for chain elongation. The ligand was coupled to 1,4-butanediamine, tris-(2-ethylamino)amine, pentaerythrityltetramine and PAMAM dendrimers (1,4-butanodiamine core G0 and 1,12-dodecanediamine core G0). The unprotected glycodendrimers were purified by size-exclusion chromatography (SEC). This was the only step in which a chromatographic method was employed throughout the synthetic route. This is a new and efficient strategy for the preparation of neoglycoconjugates.
