1401693-67-1Relevant articles and documents
[5C+1N] Annulations: Two novel Routes to Substituted Dihydrofuro[3,2-c] Pyridines
Huang, Peng,Zhang, Rui,Liang, Yongjiu,Dong, Dewen
supporting information, p. 5196 - 5199,4 (2012/12/12)
Two novel routes based on [5C + 1N] annulations for the synthesis of 2,3-dihydrofuro[3,2-c]pyridines are described. Ammonium acetate (NH 4OAc) is used as an ammonia source in both routes. The first route utilizes 1-acyl-1-[(dimethylamino)alkenoyl]cyclopropanes as a five-carbon 1,5-bielectrophilic species and combines the [5C + 1N] annulation and regioselective ring-enlargement of cyclopropyl ketone into one pot, whereas the second route utilizes 3-acyl-2-[(dimethylamino)alkenyl]-4,5-dihydrofurans as the five-carbon synthons, which involves a sequential intermolecular aza-addition, intramolecular aza-nucleophilic addition/elimination, and dehydration reaction.