1401693-68-2

Upstream product

• 1401693-76-2 (E)-1-(2-(2-(dimethylamino)vinyl)-5-(p-tolyl)-4,5-dihydrofuran-3-yl)ethanone 
• 58634-70-1 1,1-Diacetyl-2-(p-methylphenyl)cyclopropan 
• 134391-03-0 3-acetyl-2-methyl-5-p-tolyl-4,5-dihydrofuran 
• 1401693-57-9 (E)-1-(1-acetyl-2-p-tolylcyclopropyl)-3-(dimethylamino)prop-2-en-1-one 

Relevant academic research and scientific papers

[5C+1N] Annulations: Two novel Routes to Substituted Dihydrofuro[3,2-c] Pyridines

Two novel routes based on [5C + 1N] annulations for the synthesis of 2,3-dihydrofuro[3,2-c]pyridines are described. Ammonium acetate (NH 4OAc) is used as an ammonia source in both routes. The first route utilizes 1-acyl-1-[(dimethylamino)alkenoyl]cyclopropanes as a five-carbon 1,5-bielectrophilic species and combines the [5C + 1N] annulation and regioselective ring-enlargement of cyclopropyl ketone into one pot, whereas the second route utilizes 3-acyl-2-[(dimethylamino)alkenyl]-4,5-dihydrofurans as the five-carbon synthons, which involves a sequential intermolecular aza-addition, intramolecular aza-nucleophilic addition/elimination, and dehydration reaction.