140170-83-8

Usage

Uses

Used in Pharmaceutical Industry:
(R)-ethyl 2-aminohexanoate is used as a chiral building block for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of enantiomerically pure compounds, which are essential in the development of effective and safe medications.
Used in Agrochemical Industry:
In the agrochemical industry, (R)-ethyl 2-aminohexanoate serves as a crucial component in the synthesis of specific agrochemicals. Its chiral nature enables the production of targeted and efficient products, reducing potential environmental impact.
Used in Flavor and Fragrance Industry:
(R)-ethyl 2-aminohexanoate is utilized as a key ingredient in the development of flavors and fragrances. Its distinctive properties contribute to the creation of unique and complex scents, enhancing the sensory experience of various products.
Used in Chemical Research:
As a reagent in chemical reactions, (R)-ethyl 2-aminohexanoate plays a significant role in advancing scientific research. Its versatile nature allows for the exploration of new chemical pathways and the discovery of novel compounds with potential applications in various fields.

Upstream product

• 97611-56-8 ethyl N-(diphenylmethylene)-2-aminohexanoate 
• 140170-78-1 (R)-2-[Benzyl-((R)-2-hydroxy-1-phenyl-ethyl)-amino]-hexanoic acid ethyl ester 

Downstream Products

• 80696-28-2 (2R)-2-amino-2-butyl-1-ethanol 

Relevant academic research and scientific papers

Design and synthesis of a s-triazene based asymmetric organocatalyst and its application in enantioselective alkylation

A very efficient chiral organocatalyst was prepared from the readily available cyanuric chloride. The asymmetric catalyst exhibited a highly enantioselective catalytic performance for the alkylation of a glycinate Schiff base, which provides a useful procedure for the enantioselective synthesis of structurally diverse natural and unnatural α-alkyl-α-amino acids.

A New Chiral Glycine Synthon. Synthesis, X-Ray Structure of (-)-(2S,4R)-2-Ethoxycarbonyl-4-phenyl-1,3-oxazolidine and Diastereoselective Nucleophilic Ring Opening to (R)-Ethyl α-Amino Carboxylates.

Condensation of (R)-N-benzyl-2-phenylglycinol 1 with the methyl hemiacetal of ethyl glyoxylate leads to (2S,4R)-2-ethoxycarbonyl-4-phenyl-1,3-oxazolidine 2 as the major product, obtained as a pure enantiomer after column chromatography.Compound 2 is stereoselectively cleaved by dialkylzinc reagents, prepared from alkylmagnesium iodides and ZnCl2, with moderate to good d.e. (72-94 percent).These compounds, after separation by column chromatography and debenzylation by hydrogenolysis in the presence of 10percent Pd on carbon, lead to enantiomerically pure ethyl α-amino carboxylates with good chemical yields. Key words: Chiral Oxazolidines, alpha-amino Esters, Chiral Glycine Synthon, Ring Opening, Asymmetric Synthesis