140170-92-9

Basic information

• Product Name: Boc-Phe-Sar-Ψ(CH2-NH)-Leu-Met(O2)-NH2
• CAS NO: 140170-92-9
• Molecular Weight: 597.776
• Mol File: 140170-92-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Boc-Phe-Sar-Ψ(CH2-NH)-Leu-Met(O2)-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Phe-Sar-Ψ(CH2-NH)-Leu-Met(O2)-NH2(140170-92-9)
• EPA Substance Registry System: Boc-Phe-Sar-Ψ(CH2-NH)-Leu-Met(O2)-NH2(140170-92-9)

Safety Data

• Hazardous Substances Data: 140170-92-9(Hazardous Substances Data)

Upstream product

• 24608-52-4 tert-butyl chloroformate 
• 140171-17-1 TFA*Leu-Met(O₂)-NH₂ 
• 140170-91-8 Boc-Sar-Ψ(CH2-NH)-Leu-Met(O2)-NH2 
• 140170-89-4 Boc-Leu-Met(O₂)-NH₂ 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 119206-32-5 C₁₉H₂₇NO₆ 
• 140171-19-3 TFA*Sar-Ψ(CH2-NH)-Leu-Met(O2)-NH2 

Downstream Products

• 140170-93-0 Boc-Phe-Phe-Sar-Ψ(CH2-NH)-Leu-Met(O2)-NH2 

Relevant articles and documents

Synthesis and biological activities of neurokinin pseudopeptide analogues containing a reduced peptide bond

A series of pseudopeptides, analogues of neurokinin selective agonists, in which a peptide bond was replaced by a (CH2NH) bond were synthesized. The biological activities of these compounds were determined on selective pharmacological preparations: the dog carotid artery for NK-1, the rabbit pulmonary artery devoid of endothelium for the NK-2 and the rat portal vein for the NK-3 receptors. The results reported in this study indicate that insertion of a pseudopeptide bond in various positions of these selective agonists resulted in a great decrease in potency compared to the parent compounds. Furthermore, the selectivity of agonists is maintained by the use of a methylene amino group in position 9-10 (Sar) for the NK-1 or in position 7-8 (MePhe) for the NK-3 selective compound. The selectivity is greatly diminished for the NK-2 analogues.