140171-07-9

Basic information

• Product Name: Boc-Phe-Phe-MePhe-Gly-Ψ(CH2-NH)-Leu-Met-NH2
• CAS NO: 140171-07-9
• Molecular Weight: 860.131
• Mol File: 140171-07-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Boc-Phe-Phe-MePhe-Gly-Ψ(CH2-NH)-Leu-Met-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Phe-Phe-MePhe-Gly-Ψ(CH2-NH)-Leu-Met-NH2(140171-07-9)
• EPA Substance Registry System: Boc-Phe-Phe-MePhe-Gly-Ψ(CH2-NH)-Leu-Met-NH2(140171-07-9)

Safety Data

• Hazardous Substances Data: 140171-07-9(Hazardous Substances Data)

Upstream product

• 24608-52-4 tert-butyl chloroformate 
• 37553-65-4 Boc-N-Me-Phe-OH 
• 119206-32-5 C₁₉H₂₇NO₆ 
• 140171-06-8 Boc-Phe-MePhe-Gly-Ψ(CH2-NH)-Leu-Met-NH2 
• 140171-05-7 Boc-MePhe-Gly-Ψ(CH2-NH)-Leu-Met-NH2 

Relevant articles and documents

Synthesis and biological activities of neurokinin pseudopeptide analogues containing a reduced peptide bond

A series of pseudopeptides, analogues of neurokinin selective agonists, in which a peptide bond was replaced by a (CH2NH) bond were synthesized. The biological activities of these compounds were determined on selective pharmacological preparations: the dog carotid artery for NK-1, the rabbit pulmonary artery devoid of endothelium for the NK-2 and the rat portal vein for the NK-3 receptors. The results reported in this study indicate that insertion of a pseudopeptide bond in various positions of these selective agonists resulted in a great decrease in potency compared to the parent compounds. Furthermore, the selectivity of agonists is maintained by the use of a methylene amino group in position 9-10 (Sar) for the NK-1 or in position 7-8 (MePhe) for the NK-3 selective compound. The selectivity is greatly diminished for the NK-2 analogues.