1401733-56-9Relevant academic research and scientific papers
Aerobic oxidation of PdII to PdIV by active radical reactants: Direct C-H nitration and acylation of arenes via oxygenation process with molecular oxygen
Liang, Yu-Feng,Li, Xinyao,Wang, Xiaoyang,Yan, Yuepeng,Feng, Peng,Jiao, Ning
, p. 1956 - 1963 (2015/03/14)
A Pd-catalyzed aerobic oxidative C-H nitration and acylation of arenes with simple and readily available tert-butyl nitrite (TBN) and toluene as the radical precursors has been developed. Molecular oxygen is employed as the terminal oxidant and oxygen source to initiate the active radical reactants. Many different directing groups such as pyridine, pyrimidine, pyrazole, pyridol, pyridylketone, oxime, and azo groups can be employed in these novel transformations. The PdII/PdIV catalytic cycle through a radical process is the most likely pathway for these oxidative C-H nitration and acylation reactions.
Four tandem C-H activations: A sequential C-C and C-O bond making via a Pd-catalyzed cross dehydrogenative coupling (CDC) approach
Guin, Srimanta,Rout, Saroj Kumar,Banerjee, Arghya,Nandi, Shyamapada,Patel, Bhisma K.
, p. 5294 - 5297,4 (2020/09/02)
An unprecedented aroylation at the ortho C-H bond with respect to a directing group has been accomplished via a Pd(II)-catalyzed cross dehydrogenative coupling approach using alkylbenzene as the synthetic equivalent of an aroyl moiety. The reaction proceeds through sequential C-C and C-O bond making at the expense of four consecutive C-H bond cleavages (three sp 3 benzylic C-H's and one sp2 arene C-H) to selectively install an aroyl functionality at the proximal site of substrates containing various directing groups.
