140176-73-4Relevant articles and documents
Synthesis method of nizatidine drug intermediate 2-dimethylamino methyl-4-chloromethyl thiazole
-
Paragraph 0013, (2017/01/02)
A synthesis method of a nizatidine drug intermediate 2-dimethylamino methyl-4-chloromethyl thiazole includes the following steps that 0.063 mol of 2-dimethylamino methyl-4-chloromethyl-4-aminothiazoline, 310 ml of cyclohexane, 0.92 mol of stannous chloride and 0.16-0.19 mol of an ortho-nitrotoluene solution are added into a reaction vessel provided with a stirrer and a thermometer, the stirring speed is controlled to be 150-190 rpm, the solution temperature is controlled to be 10-15 DEG C, reaction is performed for 20-25 hours, then the temperature is raised to 60-65 DEG C, the reaction continues for 4-5 hours, the solution temperature is reduced to 20-25 DEG C, solid precipitation, filtration, washing with a saline solution, washing with acetonitrile and dehydration with a dehydrating agent are performed, and recrystallization is performed in triethylamine to obtain the crystal 2-dimethylamino methyl-4-chloromethyl thiazole.
A modified synthesis of 4-chloromethylthiazoles
Marzoni
, p. 577 - 580 (2007/10/02)
-