1401863-75-9

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 1401863-74-8 C₁₉H₁₈N₂O₃ 

Downstream Products

• 1401863-77-1 C₂₀H₁₈N₄O₂ 
• 1401863-79-3 N-(2-aminoethyl)-1-(3-hydroxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxamide hydrochloride 

Relevant academic research and scientific papers

PhI(OAc)2-mediated one-pot oxidative decarboxylation and aromatization of tetrahydro-β-carbolines: Synthesis of norharmane, harmane, eudistomin U and eudistomin i

Iodobenzene diacetate was employed as a mild and efficient reagent for one-pot oxidative decarboxylation of tetrahydro-β-carboline acids and dehydrogenation of tetrahydro-β-carbolines to access the corresponding aromatic β-carbolines. To the best of our knowledge this is the first synthesis of β-carbolines via a one-pot oxidative decarboxylation at ambient temperature. The utility of this protocol has been demonstrated in the synthesis of β-carboline alkaloids norharmane (2o), harmane (2p), eudistomin U (9) and eudistomin I (12).

COMPOUNDS FOR TREATMENT OF METABOLIC SYNDROME

Present invention refers to new compounds of formula I or II, its synthesis and its use in the treatment of metabolic syndrome, particularly for the treatment of type I or type II diabetes and/or metabolic syndrome or metabolic disease or metabolic disorders.