14019-10-4Relevant articles and documents
Synthesis of optically active methadones, LAAM and bufuralol by lipase-catalysed acylations
Hull, Jonathan D.,Scheinmann, Feodor,Turner, Nicholas J.
, p. 567 - 576 (2007/10/03)
(R)- and (S)-Methadones and levo-α-acetylmethadol (LAAM) have been synthesised starting from lipase-catalysed acylation of dimethylaminopropan-2-ol. An approach to the synthesis of (R)-bufuralol is also presented.
Synthesis of a new metabolite of acetylmethadol
Booher,Pohland
, p. 266 - 268 (2007/10/06)
The primary amine metabolites of α (±) and α (-) acetylmethadol were synthesized. A neutral permanganate oxidation of noracetylmethadol gave a nitroalkane. This unusual oxidation product was readily converted to the primary amine metabolite of acetylmetha