140195-93-3Relevant academic research and scientific papers
UREA DERIVATIVES AS PYRUVATE KINASE ACTIVATORS
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Paragraph 539-541, (2022/02/15)
The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.
Cyclic dipeptides with 1-aminocyclopropane-1-carboxylic acid
Kasafirek, Evzen,Moural, Jaroslav,Vinsova, Jarmila,Sturc, Antonin,Taimr, Jan
, p. 941 - 947 (2007/10/03)
Cyclic dipeptides of the formula cyclo(-Acc-X-), where Acc = 1-aminocyclopropane-1-carboxylic acid, X = Gly, Ala, Val, Leu, Phe or Tyr, were synthesized. The prepared 2,5-piperazinediones showed no proliferative or antiproliferative activity on normal hum
A fast procedure for the preparation of amides/peptides from carboxylic acids and azides via two redox reactions: Application to the synthesis of methionine enkephalin
Ghosh, Sunil K.,Verma, Rekha,Ghosh, Usha,Mamdapur, Vasant R.
, p. 1705 - 1711 (2007/10/03)
A one-pot self regulated approach for the synthesis of amides/peptides based on two reduction-oxidation (redox) reactions has been described. The primary and secondary amides/peptides are made by using azidotrimethylsilane and alkyl azides/α-azido acid de
One pot amide/peptide synthesis via two redox reactions
Ghosh,Singh,Mamdapur
, p. 805 - 808 (2007/10/02)
A new and highly efficient one-pot self-regulated approach to amide/peptide synthesis has been developed based on two redox reactions using azide as a latent amine component. For the first time, selenophenol, generated in situ has been found to be effecti
