140196-57-2

Basic information

• Product Name: {1-[5-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethyl}-carbamic acid benzyl ester
• Synonyms: {1-[5-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethyl}-carbamic acid benzyl ester
• CAS NO: 140196-57-2
• Molecular Weight: 608.734
• Mol File: 140196-57-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {1-[5-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethyl}-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {1-[5-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethyl}-carbamic acid benzyl ester(140196-57-2)
• EPA Substance Registry System: {1-[5-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethyl}-carbamic acid benzyl ester(140196-57-2)

Safety Data

• Hazardous Substances Data: 140196-57-2(Hazardous Substances Data)

Upstream product

• 137649-69-5 (2S,3R,4R,5S)-2,5-bis<<(benzyloxy)carbonyl>amino>-3,4-dihydroxy-1,6-diphenylhexane 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 136740-99-3 1-[5-(1-amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-phenyl-ethylamine 

Relevant articles and documents

Expedient solid-phase synthesis of both symmetric and asymmetric diol libraries targeting aspartic proteases

C2-symmetric diols have been shown to be highly potent against HIV-1 protease (PR). However, gaining access to these compounds has been hampered by the need of multistep solution-phase reactions which are often tedious and inefficient. In this Letter, we have disclosed a solid-phase strategy for rapid preparation of small molecule-based, symmetric and asymmetric diols as potential HIV-1 protease inhibitors. Upon biological screening, we found one of them, SYM-5, to be a potent and selective inhibitor (Ki = 400 nM) against HIV-1 protease.