Cas 1401966-32-2,1,1-dimethylethyl 4-({ [(1S,2R)-2-phenylcyclopropyl]amino}methyl)-1-piperidinecarboxylate

1401966-32-2

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Basic information

Product Name: 1,1-dimethylethyl 4-({ [(1S,2R)-2-phenylcyclopropyl]amino}methyl)-1-piperidinecarboxylate
Synonyms: 1,1-dimethylethyl 4-({ [(1S,2R)-2-phenylcyclopropyl]amino}methyl)-1-piperidinecarboxylate
CAS NO:1401966-32-2
Molecular Formula:
Molecular Weight: 330.47
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 1,1-dimethylethyl 4-({ [(1S,2R)-2-phenylcyclopropyl]amino}methyl)-1-piperidinecarboxylate(CAS DataBase Reference)
NIST Chemistry Reference: 1,1-dimethylethyl 4-({ [(1S,2R)-2-phenylcyclopropyl]amino}methyl)-1-piperidinecarboxylate(1401966-32-2)
EPA Substance Registry System: 1,1-dimethylethyl 4-({ [(1S,2R)-2-phenylcyclopropyl]amino}methyl)-1-piperidinecarboxylate(1401966-32-2)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1401966-32-2(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1401966-32-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,1,9,6 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1401966-32:
(9*1)+(8*4)+(7*0)+(6*1)+(5*9)+(4*6)+(3*6)+(2*3)+(1*2)=142
142 % 10 = 2
So 1401966-32-2 is a valid CAS Registry Number.

1401966-32-2Upstream product

137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate

1401966-32-2Downstream Products

1401966-32-2Relevant academic research and scientific papers

Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor

Wang, Xiaowen,Su, Mingbo,Li, You,Liu, Tongchao,Wang, Yujie,Chen, Yabing,Tang, Le,He, Yu-Peng,Ding, Xiaoguang,Yu, Fang,Shen, Jingkang,Li, Jia,Zhou, Yubo,Chen, Yue-Lei,Xiong, Bing

, p. 844 - 847 (2019)

Tranylcypromine moiety extracted from LSD1 inhibitors and 6-trifluoroethyl thienopyrimidine moiety from menin-MLL1 PPI inhibitors were merged to give new chemotypes for medicinal chemistry study. Among 15 new compounds prepared in this work, some exhibited nanomolar LSD1 activity and good selectivity over MAO-A/B, low micromolar menin-MLL1 PPI inhibitory activity, as well as submicromolar MV4-11 antiprofilative activities. Intracellular LSD1 engagement of compounds with higher enzymatic and antiproliferative activities was confirmed by CD86 mRNA up-regulation experiments.

Cyclopropylamines as LSD1 inhibitors

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Page/Page column 39; 40; 41, (2016/06/14)

This invention relates to the use of cyclopropylamine derivatives for the modulation, notably the inhibition of the activity of Lysine-specific demethylase 1 (LSD1). Suitably, the present invention relates to the use of cyclopropylamines in the treatment of cancer.

LSD1 Fluorocyclopropylamine as inhibitor

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Paragraph 0165, (2016/10/09)

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