1401998-13-7

Basic information

• Product Name: 1-(3,4-difluorophenyl)-4-bromo-5-(4-methylsulfonylphenyl)imidazole
• Synonyms: 1-(3,4-difluorophenyl)-4-bromo-5-(4-methylsulfonylphenyl)imidazole
• CAS NO: 1401998-13-7
• Molecular Weight: 413.242
• Mol File: 1401998-13-7.mol

Chemical Properties

• CAS DataBase Reference: 1-(3,4-difluorophenyl)-4-bromo-5-(4-methylsulfonylphenyl)imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-difluorophenyl)-4-bromo-5-(4-methylsulfonylphenyl)imidazole(1401998-13-7)
• EPA Substance Registry System: 1-(3,4-difluorophenyl)-4-bromo-5-(4-methylsulfonylphenyl)imidazole(1401998-13-7)

Safety Data

• Hazardous Substances Data: 1401998-13-7(Hazardous Substances Data)

Upstream product

• 1239358-07-6 C₁₆H₁₂F₂N₂O₂S 

Relevant articles and documents

Synthesis of 1,5-diarylhaloimidazole analogs and their inhibitory activities against PGE2 production from LPS-treated RAW 264.7 cells

A number of 1,5-diarylimidazole analogs were synthesized and evaluated their inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin E 2 production. Reactions of 1,5-diarylimidazoles with halogenating reagents (NCS, NBS, NIS) afforded halogenated analogs. Among the analogs tested, compounds Ib, IIa, IIb and IIe exhibited significantly improved inhibitory activities against COX-2-mediated PGE2 production from LPS-induced RAW 264.7 cells compared to those of the parent 1,5-diarylimidazoles. Especially, the analogs Ib (IC50 = 0.55 μM) and IIa (IC 50 = 0.58 μM) showed best results. Halogenation on the 1,5-diarylimidazole ring enhanced inhibitory activities against COX-2 catalyzed PGE2 production, however, inhibitory activities were significantly varied by position(s) and species of the substituted halogen(s).

Synthesis of 1,5-diarylhaloimidazole analogs and their inhibitory activities against PGE2 production from LPS-treated RAW 264.7 cells

A number of 1,5-diarylimidazole analogs were synthesized and evaluated their inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin E 2 production. Reactions of 1,5-diarylimidazoles with halogenating reagents (NCS, NBS, NIS) afforded halogenated analogs. Among the analogs tested, compounds Ib, IIa, IIb and IIe exhibited significantly improved inhibitory activities against COX-2-mediated PGE2 production from LPS-induced RAW 264.7 cells compared to those of the parent 1,5-diarylimidazoles. Especially, the analogs Ib (IC50 = 0.55 μM) and IIa (IC 50 = 0.58 μM) showed best results. Halogenation on the 1,5-diarylimidazole ring enhanced inhibitory activities against COX-2 catalyzed PGE2 production, however, inhibitory activities were significantly varied by position(s) and species of the substituted halogen(s).