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Actinomycin E2 is a naturally occurring antibiotic and enediyne antitumor agent derived from the bacterium Streptomyces parvulus. It is a member of the actinomycin family, which is known for its potent cytotoxic properties. Actinomycin E2 inhibits DNA transcription by intercalating into the DNA helix and forming a covalent bond with the deoxyguanosine residues, thereby preventing RNA polymerase from transcribing the DNA template. This mechanism of action makes it effective against various types of cancer, including leukemia and certain solid tumors. The chemical structure of Actinomycin E2 consists of a phenoxazone chromophore, a peptide chain, and a unique enediyne warhead, which is responsible for its high reactivity and DNA-damaging capabilities. Due to its potent cytotoxicity and potential side effects, Actinomycin E2 is primarily used in research settings to study the mechanisms of DNA damage and repair, as well as in the development of new anticancer drugs.

1402-42-2

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1402-42-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1402-42-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,0 and 2 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1402-42:
(6*1)+(5*4)+(4*0)+(3*2)+(2*4)+(1*2)=42
42 % 10 = 2
So 1402-42-2 is a valid CAS Registry Number.

1402-42-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-amino-1-N,9-N-bis[3,10-di(butan-2-yl)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboxamide

1.2 Other means of identification

Product number -
Other names Actinomycin E2

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1402-42-2 SDS

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