Actinomycin F0 is a naturally occurring, cyclic peptide antibiotic produced by certain strains of Streptomyces bacteria. It is a member of the actinomycin family, which is known for its antitumor and antifungal properties. Actinomycin F0 is characterized by its ability to intercalate into DNA, thereby inhibiting RNA synthesis and ultimately leading to the disruption of protein synthesis in target cells. This mechanism of action makes it a potent agent against rapidly dividing cells, which is why it has been studied for its potential use in cancer treatment. The chemical structure of actinomycin F0 consists of a phenoxazone chromophore linked to a cyclic peptide containing three amino acids: two molecules of sarcosine and one molecule of 2-methyl-tryptophan. Due to its significant side effects, including nephrotoxicity and bone marrow suppression, its clinical use is limited, and it is primarily of interest for research purposes in understanding the mechanisms of DNA-drug interactions.

1402-43-3

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Basic information
1. Product Name: actinomycin F0
2. Synonyms: actinomycin F0
3. CAS NO:1402-43-3
4. Molecular Formula:
5. Molecular Weight: 0
6. EINECS: N/A
7. Product Categories: N/A
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: N/A
3. Flash Point: N/A
4. Appearance: /
5. Density: N/A
6. Refractive Index: N/A
7. Storage Temp.: N/A
8. Solubility: N/A
9. CAS DataBase Reference: actinomycin F0(CAS DataBase Reference)
10. NIST Chemistry Reference: actinomycin F0(1402-43-3)
11. EPA Substance Registry System: actinomycin F0(1402-43-3)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. RIDADR: 3249
5. WGK Germany:
6. RTECS:
7. HazardClass: 6.1(a)
8. PackingGroup: II
9. Hazardous Substances Data: 1402-43-3(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1402-43-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,0 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1402-43:
(6*1)+(5*4)+(4*0)+(3*2)+(2*4)+(1*3)=43
43 % 10 = 3
So 1402-43-3 is a valid CAS Registry Number.

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