1402002-76-9

Basic information

• Product Name: 2-[(2S)-1-{4-fluoro-2-[(2R)-1,1,1-trifluoropropan-2-yl]phenoxy}propan-2-yl]-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione
• Synonyms: 2-[(2S)-1-{4-fluoro-2-[(2R)-1,1,1-trifluoropropan-2-yl]phenoxy}propan-2-yl]-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione
• CAS NO: 1402002-76-9
• Molecular Weight: 492.473
• Mol File: 1402002-76-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[(2S)-1-{4-fluoro-2-[(2R)-1,1,1-trifluoropropan-2-yl]phenoxy}propan-2-yl]-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2S)-1-{4-fluoro-2-[(2R)-1,1,1-trifluoropropan-2-yl]phenoxy}propan-2-yl]-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione(1402002-76-9)
• EPA Substance Registry System: 2-[(2S)-1-{4-fluoro-2-[(2R)-1,1,1-trifluoropropan-2-yl]phenoxy}propan-2-yl]-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione(1402002-76-9)

Safety Data

• Hazardous Substances Data: 1402002-76-9(Hazardous Substances Data)

Usage

Structure

Complex molecule with a long and specific structure

Functional Groups

Fluoro substituent
Trifluoropropan-2-yl group
4-methyl-1H-imidazol-1-yl group

Chemical Class

Belongs to the pyrido[1,2-a]pyrazine-1,6-dione class

Potential Applications

Likely a pharmaceutical or research chemical
May possess biological activity

Further Investigation

Precise function and applications require further investigation and analysis

Upstream product

• 1402004-12-9 4-fluoro-1-methoxy-2-(3,3,3-trifluoroprop-1-en-2-yl)benzene 
• 179897-94-0 (5-fluoro-2-methoxyphenyl)boronic acid 
• 1402004-16-3 7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydropyrido[2,1-c]-[1,4]oxazine-1,6-dione 
• 1402003-83-1 5-(4-Methyl-1H-imidazol-1-yl)-6-oxo-1,6-dihydropyridine-2-carboxylic acid, hydrochloride salt 
• 1262197-81-8 methyl 6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridine-2-carboxylate 
• 1123194-98-8 6-bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine 

Relevant articles and documents

Design of pyridopyrazine-1,6-dione γ-secretase modulators that align potency, MDR efflux ratio, and metabolic stability

Herein we describe the design and synthesis of a series of pyridopyrazine-1,6-dione γ-secretase modulators (GSMs) for Alzheimer's disease (AD) that achieve good alignment of potency, metabolic stability, and low MDR efflux ratios, while also maintaining favorable physicochemical properties. Specifically, incorporation of fluorine enabled design of metabolically less liable lipophilic alkyl substituents to increase potency without compromising the sp3-character. The lead compound 21 (PF-06442609) displayed a favorable rodent pharmacokinetic profile, and robust reductions of brain Aβ42 and Aβ40 were observed in a guinea pig time-course experiment.