1402073-60-2Relevant academic research and scientific papers
Chemical transformations of mackinazolinone and its derivativesa
Nasrullaev,Turdibaev,Elmuradov,Yili,Aisa,Shakhidoyatov
, p. 638 - 642 (2013/02/22)
The thioanalog of mackinazolinone (2,3,4,10-tetrahydro-1H-pyrido[2,1-b] quinazolin-10-one) was synthesized for the first time by reacting it with P2S5. The thioanalog was reacted with aromatic aldehydes and Vilsmeier- Haack reagent (DMF + POCl3) to produce 4-arylidene- and - hydroxymethylidenemackinazolinthiones, respectively. The reactions of 4-hydroxymethylidenemackinazolinone with isomeric aminophenols and aminobenzoic acids and of hydroxymethylidenemackinazolinthione with thionylchloride were studied. Subsequent reaction of the obtained 4-chloromethylidene derivative with sodium hydroselenide was synthesized a new Se-containing derivative of mackinazolinone. It was shown that 4-formylmackinazolinthione existed in the enol form whereas 4-formylmackinazolinone existed as the enaminoaldehyde tautomer.
