1402089-76-2Relevant academic research and scientific papers
Highly selective synthesis of (E)-alkenyl-(pentafluorosulfanyl)benzenes through Horner-Wadsworth-Emmons reaction
Iakobson, George,Beier, Petr
, p. 1185 - 1190 (2012/09/08)
Diethyl 2-nitro-(pentafluorosulfanyl)benzylphosphonates, available by the vicarious nucleophilic substitution reaction of meta- and para-nitro- (pentafluorosulfanyl)benzenes and diethyl chloromethylphosphonate, undergo Horner-Wadsworth-Emmons reaction with aldehydes in the presence of potassium hydroxide in acetonitrile at ambient temperature to give (E)-2-nitro-1-alkenyl- (pentafluorosulfanyl) benzenes in good yields and high stereoselectivities. Follow-up transformations of the primary products provided (E)-1-alkenyl- (pentafluorosulfanyl)benzenes and 2-(2-arylethyl)-(pentafluorosulfanyl)anilines.
