140209-70-7

Upstream product

• 126456-55-1 1,2-O-(1-methoxy)ethylidene-3,4,6,7-tetra-O-benzyl-L-glycero-β-D-manno-heptopyranose 
• 116302-70-6 2-O-Acetyl-3,4,6,7-tetra-O-benzyl-L-glycero-α-D-manno-heptopyranosylchlorid 
• 75-08-1 ethanethiol 
• 188435-09-8 Acetic acid (2R,3S,4S,5S,6R)-4,5-bis-benzyloxy-6-((S)-1,2-bis-benzyloxy-ethyl)-2-ethylsulfanyl-tetrahydro-pyran-3-yl ester 

Downstream Products

• 188435-20-3 C₆₀H₆₆F₃NO₁₈ 
• 188435-18-9 C₆₈H₇₄F₃NO₁₉ 
• 140209-79-6 (2R,4R,5R,6R)-4-Benzyloxy-2-(3-benzyloxycarbonylamino-propoxy)-5-[(2S,3S,4R,5S,6R)-4,5-bis-benzyloxy-6-((S)-1,2-bis-benzyloxy-ethyl)-3-hydroxy-tetrahydro-pyran-2-yloxy]-6-((R)-1,2-dihydroxy-ethyl)-tetrahydro-pyran-2-carboxylic acid 
• 140209-77-4 Ethyl onate 
• 140209-78-5 Ethyl onate 
• 188435-32-7 ethyl O-(2,3,4,6-tetra-O-benzoyl-α-D-galactopyranosyl)-(1-> 2)-O-3,4,6,7-tetra-O-benzyl-1-thio-L-glycero-α-D-manno-heptopyranoside 
• 188435-15-6 (2R,3S,4S,5S,6R)-3,4-Bis-benzyloxy-2-((S)-1,2-bis-benzyloxy-ethyl)-6-ethylsulfanyl-5-(4-methoxy-benzyloxy)-tetrahydro-pyran 
• 140209-71-8 Ethyl 2-O-benzoyl-3,4,6,7-tetra-O-benzyl-1-thio-L-glycero-D-manno-heptopyranoside 

Relevant academic research and scientific papers

Synthesis of L-glycero-D-manno-heptopyranose-containing oligosaccharide structures found in lipopolysaccharides from Haemophilus influenzae

Syntheses are described of the tetrasaccharide 2-(4-trifluoroacetamidophenyl)ethyl O-(β-D-galactopyranosyl)-(1 → 2)-O-(L-glycero-α-D-manno-heptopyranosyl)-(1 → 2)-O-(L-glycero-α-D-manno-heptopyranosyl)-(1 → 3)-L-glycero-α-D-manno-heptopyranoside (20) and the three trisaccharides 2-(4-trifluoroacetamidophenyl)ethyl O-(L-glycero-α-D-manno-heptopyranosyl)-(1 → 2)-O-(L-glycero-α-D-manno-heptopyranosyl)-(1 → 3)-L-glycero-α-D-manno-heptopyranoside (17), 2-(4-trifluoroacetamidophenyl)ethyl O-(β-D-glucopyranosyl)-(1 → 4)-O-(β-D-glucopyranosyl)-(1 → 4)-L-glycero-α-D-manno-heptopyranoside (5), and 2-(4-trifluoroacetamidophenyl)ethyl O-(β-D-galactopyranosyl)-(1 → 4)-O-(β-D-glucopyranosyl)-(1 → 4)-L-glycero-α-D-manno-heptopyranoside (8), corresponding to structures found in the lipooligosaccharides of Haemophilus influenzae.

Synthesis of LD-Hepp and KDO containing di- and tetrasaccharide derivatives of Neisseria meningitidis inner-core region via iodonium ion promoted glycosidations

The synthesis of methyl(ethyl) 2-thio-KDO (i.e. 1, 2, 5, 7 and 10) and ethyl 1-thio-LD-Hepp (i.e. 26 and 43) derivatives will be described.The latter derivatives proved to be suitable donors in iodonium ion (NIS/TfOH) promoted glycosidation reactions.The