14021-76-2

Upstream product

• 110-85-0 piperazine 
• 2152-34-3 2-amino-5-phenyl-4-oxazolinone 

Downstream Products

• 57260-22-7 1-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-4-(3-pyridin-4-yl-acryloyl)-piperazine 
• 57260-24-9 1-[3-(5-nitro-furan-2-yl)-acryloyl]-4-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-piperazine 
• 57260-19-2 1-benzoyl-4-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-piperazine 
• 57260-20-5 1-(4-chloro-benzoyl)-4-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-piperazine 
• 57259-99-1 1-[3-(2-methoxy-phenyl)-acryloyl]-4-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-piperazine 
• 57260-00-1 1-[3t-(3-methoxy-phenyl)-acryloyl]-4-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-piperazine 
• 57259-92-4 1-[3-(4-nitro-phenyl)-acryloyl]-4-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-piperazine 
• 57260-16-9 1-[(4-methoxy-phenyl)-acetyl]-4-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-piperazine 
• 57260-30-7 2-{4-[3-hydroxy-3-(4-methoxy-phenyl)-propyl]-piperazin-1-yl}-5-phenyl-oxazol-4-one 
• 57260-29-4 2-[4-(2-adamantan-1-yl-2-hydroxy-ethyl)-piperazin-1-yl]-5-phenyl-oxazol-4-one 
• 57260-32-9 2-[4-(2-hydroxy-2-thiophen-2-yl-ethyl)-piperazin-1-yl]-5-phenyl-oxazol-4-one 
• 57259-97-9 1-[3-(4-acetylamino-phenyl)-acryloyl]-4-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-piperazine 
• 57260-23-8 1-(6-methoxy-3,4-dihydro-naphthalene-2-carbonyl)-4-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-piperazine 
• 57259-98-0 1-[3-(4-ethoxy-phenyl)-acryloyl]-4-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-piperazine 

Relevant academic research and scientific papers

Antidepressant and anticonvulsant activity of 1 (5 phenyl 4 oxo 2 oxazolin 2 yl) 4 substituted piperazines

1 (5 Phenyl 4 oxo 2 oxazolin 2 yl) 4 substituted cinnamoylpiperazines and 1 (5 phenyl 4 oxo 2 oxazolin 2 yl) 4 carbamoylpiperazine and derivatives were synthesized and evaluated for antidepressant activity in the mouse Dopa potentiation test. 1 (5 Phenyl

Antimalarials. Synthesis and antimalarial activity of 1 (4 methoxycinnamoyl) 4 (5 phenyl 4 oxo 2 oxazolin 2 yl)piperazine and derivatives

The preparation and activity against Plasmodium berghei of derivatives of 1 (4 methoxycinnamoyl) 4 (5 phenyl 4 oxo 2 oxazolin 2 yl)piperazine are described. Replacement of the cinnamoyl group was accomplished by acylation or alkylation of 1 (5 phenyl 4 oxo 2 oxazolin 2 yl)piperazine. Modifications of the 5 phenyl group were prepared either by a sequence of reactions involving mandelic ester pemoline piperazine pemoline or by the reaction of 5 aryl 2 thio 2,4 oxazolidinedione with piperazine or N substituted piperazines. In a similar manner, pemoline was allowed to react with N arylpiperazine, hexahydro 1H 1,4 diazepine, and 2,6 dimethylpiperazine to provide N arylpiperazine pemoline derivatives and variations in the piperazine moiety. Several compounds in which the 2 oxazolin 4 one ring was replaced with other heterocyclic rings were prepared as were several open chain analogs. Five compounds (three of them substituted in the para position of the 5 phenyl group and two N arylpiperazine pemoline derivatives) were found to be active against Plasmodium berghei. The remaining active compound possessed changes in the cinnamoyl group and substitution on the 5 phenyl group.