1402132-72-2Relevant academic research and scientific papers
Gold-catalyzed one-step construction of 2,3-dihydro-1H-pyrrolizines with an electron-withdrawing group in the 5-position: A formal synthesis of 7-methoxymitosene
Yan, Ze-Yi,Xiao, Yuanjing,Zhang, Liming
, p. 8624 - 8627 (2012/09/25)
What a ring formation! Bicyclic dihydropyrrolizines with an electron-withdrawing group (EWG) at the 5-position are formed in one step from linear azidoenynes under gold catalysis. This novel route involves the use of azide as a nitrene precursor, electronically-controlled regioselectivity, and the generation of destabilized 1-azapentadienium ions and their pericyclic reactions. This method was used for a formal synthesis of 7-methoxymitosene (see scheme).
