1402140-66-2

Upstream product

• 1402140-64-0 (1Z)-3-(trimethylsilyl)-1-phenyl-2-propyn-1-one O-[(4-methoxyphenyl)methyl]oxime 
• 50-00-0 formaldehyd 
• 1402140-65-1 (1E)-1-phenyl-2-propyn-1-one O-[(4-methoxyphenyl)methyl]oxime 
• 13829-77-1 3-(trimethylsilyl)-1-phenyl-2-propyn-1-one 
• 21038-22-2 O-(4-methoxybenzyl)hydroxylamine 

Downstream Products

• 1402140-76-4 4-[(4-methoxyphenyl)methyl]-3-phenyl-5-isoxazolemethanol 
• 1402140-67-3 (1Z)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-phenyl-2-butyn-1-one O-[(4-methoxyphenyl)methyl]oxime 

Relevant academic research and scientific papers

Copper-catalyzed synthesis of trisubstituted isoxazoles via a cascade cyclization-migration process

An atom-economical, catalytic, and regioselective synthesis of 3,4,5-trisubstituted isoxazoles has been successfully developed. Treatment of O-arylmethyl alkynyl oxime ethers with 5 mol % of Cu(OTf)2 in chlorobenzene at reflux gave 4-arylmethylisoxazoles in good to excellent yields via the sequential intramolecular addition of the oxime moiety to the alkyne with subsequent 1,3-migration of the arylmethyl group.