1402140-89-9Relevant academic research and scientific papers
Copper-catalyzed synthesis of trisubstituted isoxazoles via a cascade cyclization-migration process
Ueda, Masafumi,Sugita, Shoichi,Sato, Aoi,Miyoshi, Tetsuya,Miyata, Okiko
, p. 9344 - 9351,8 (2012/12/11)
An atom-economical, catalytic, and regioselective synthesis of 3,4,5-trisubstituted isoxazoles has been successfully developed. Treatment of O-arylmethyl alkynyl oxime ethers with 5 mol % of Cu(OTf)2 in chlorobenzene at reflux gave 4-arylmethylisoxazoles in good to excellent yields via the sequential intramolecular addition of the oxime moiety to the alkyne with subsequent 1,3-migration of the arylmethyl group.
