1402148-35-9Relevant academic research and scientific papers
A chemoenzymatic total synthesis of the neurogenic starfish ganglioside LLG-3 using an engineered and evolved synthase
Rich, Jamie R.,Withers, Stephen G.
supporting information; experimental part, p. 8640 - 8643 (2012/10/23)
An LLG-3 oligosaccharide-fluoride (see scheme) can be assembled chemoenzymatically and readily coupled with various sphingosines by an engineered endoglycoceramidase glycosynthase. The lyso?ganglioside products are acylated to generate the individual isomers identified in the heterogeneous natural isolates, as well as modified glycosphingolipids.
