1402162-75-7Relevant academic research and scientific papers
125I-radiolabeled morpholine-containing arginine-glycine- aspartate (RGD) ligand of αvβ3 integrin as a molecular imaging probe for angiogenesis
Bianchini, Francesca,Cini, Nicoletta,Trabocchi, Andrea,Bottoncetti, Anna,Raspanti, Silvia,Vanzi, Eleonora,Menchi, Gloria,Guarna, Antonio,Pupi, Alberto,Calorini, Lido
, p. 5024 - 5033 (2012)
In this paper, using a hybrid small-animal Micro SPECT/CT imaging system, we report that a new 125I-Cilengitide-like RGD-cyclopentapeptide, containing d-morpholine-3-carboxylic acid, interacts in vivo with αvβ3 integrin expressed by melanoma cells. Images clearly show that the 125I-compound has the capacity to monitor the growth of a melanoma xenograft. Indeed, retention of the labeled ligand in the tumor mass has a good tumor/background ratio, and a significant reduction of its uptake was observed after injection of unlabeled ligand. These results suggest that the use of 125I-labeled morpholine-based RGD-cyclopentapeptides targeting αvβ3 positive tumors may play a role in future therapeutic strategies.
