1402170-35-7Relevant academic research and scientific papers
Synthetic studies on chartelline C: Stereoselective construction of the core skeleton
Iwasaki, Kotaro,Kanno, Rentaro,Morimoto, Toshiharu,Yamashita, Tohru,Yokoshima, Satoshi,Fukuyama, Tohru
, p. 9160 - 9163 (2012/10/30)
What a core-ker! The title synthesis was achieved using a route featuring an intramolecular Mitsunobu reaction of a nosyl amide, stereoselective construction of the β-lactam, and formation of an enamide moiety by selenoxide elimination. The stereochemistry of the alkylation for the formation of the β-lactam was controlled by a secondary hydroxy group on the ten-membered ring. SEM=2-(trimethylsilyl)ethoxymethyl; TBS=tert- butyldimethylsilyl. Copyright
