140221-60-9Relevant academic research and scientific papers
QUINOLINE DERIVATIVES AND USE THEREOF AS ANGIOTENSIN II ANTAGONISTS
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, (2008/06/13)
The invention concerns pharmaceutically useful novel compounds of the formula I, in which R 1, R 2, R 3, R 4, R 5, Ra, A, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment. STR1
New nonpeptide angiotensin II receptor antagonists. 2. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4- (biphenylylmethoxy)quinoline derivatives
Bradbury,Allott,Dennis,Fisher,Major,Masek,Oldham,Pearce,Rankine,Revill,Roberts,Russell
, p. 4027 - 4038 (2007/10/02)
A novel series of nonpeptidic angiotensin II (AII) receptor antagonists is reported, derived from linkage of the biphenylcarboxylic acid or biphenylyltetrazole moiety found in previously described antagonists via a methyleneoxy chain to the 4-position of
