140221-61-0Relevant academic research and scientific papers
QUINOLINE DERIVATIVES AND USE THEREOF AS ANGIOTENSIN II ANTAGONISTS
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, (2008/06/13)
The invention concerns pharmaceutically useful novel compounds of the formula I, in which R 1, R 2, R 3, R 4, R 5, Ra, A, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment. STR1
Process for the preparation of nitriles
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, (2008/06/13)
The invention provides a novel process for the manufacture of biphenylcarbonitriles of the formula I as defined hereinafter which are useful for the production of certain known imidazole derivatives and certain novel quinoline derivatives which have angio
