1402230-41-4Relevant academic research and scientific papers
Highly diastereo- and enantioselective synthesis of α-alkyl norstatine derivatives: Catalytic asymmetric mannich reactions of 5H-Oxazol-4-ones
Zhao, Depeng,Wang, Linqing,Yang, Dongxu,Zhang, Yixin,Wang, Rui
supporting information; experimental part, p. 7523 - 7527 (2012/10/08)
Going Mannich: The title reaction results in the first catalytic asymmetric synthesis of syn-α-alkyl norstatine derivatives. Excellent enantioselectivities and diastereoselectivities were achieved with a series of N-diphenylphosphinoyl-protected imines and 5H-oxazol-4-ones by using the catalyst 1/Zn. Importantly, the involvement of the diethyl phosphoramidate 2 was critical to achieve good enantioselectivities in the present Mannich reaction. Copyright
