1402230-85-6

Basic information

• Product Name: C₁₀H₈F₄O
• CAS NO: 1402230-85-6
• Molecular Weight: 220.167
• Mol File: 1402230-85-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₀H₈F₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₈F₄O(1402230-85-6)
• EPA Substance Registry System: C₁₀H₈F₄O(1402230-85-6)

Safety Data

• Hazardous Substances Data: 1402230-85-6(Hazardous Substances Data)

Upstream product

• 21172-41-8 3-[3-(trifluoromethyl)phenyl]propanal 

Downstream Products

• 1402230-89-0 C₁₁H₉F₇O₃S 
• 1402230-87-8 (2R)-2-fluoro-3-(meta-(trifluoromethyl)phenyl)propan-1-ol 
• 1402392-51-1 C₂₂H₂₁F₄N 
• 1402230-82-3 (2R,1′R)-2-fluorocinacalcet hydrochloride 

Relevant articles and documents

Allosteric agonists of the calcium receptor (CaR): Fluorine and SF 5 analogues of cinacalcet

Three selectively fluorinated cinacalcet analogues are prepared and their activity as calcium-sensing receptor (CaR) agonists is assessed. Individual (2R,1′R)-2 and (2S,1′R)-3 fluorocinacalcet diastereoisomers were prepared using the MacMillan asymmetric fluorination reaction. Assays with the recombinant human CaR revealed that both diastereoisomers have a similar potency to each other although slightly lower (75-80%) than that of cinacalcet 1. The SF5-cinacalcet analogue 4 was prepared from meta-pentafluorosulfanyl benzyl alcohol and has ～75% agonist activity relative to cinacalcet 1 indicating that the SF5 group can replace the CF3 group and retain significant bioactivity.