1402265-29-5Relevant academic research and scientific papers
Live-cell imaging of cyclopropene tags with fluorogenic tetrazine cycloadditions
Yang, Jun,?e?kute, Jolita,Cole, Christian M.,Devaraj, Neal K.
, p. 7476 - 7479 (2012)
Spotlight on lipids: One of the major limitations of tetrazine bioorthogonal cycloadditions is the requirement of bulky dienophile reaction partners. Methylcyclopropene tags were designed capable of reacting rapidly with tetrazines while maintaining stability in aqueous solution. The suitability of these probes for bioconjugation is shown by imaging cyclopropene-modified phospholipids in live human cancer cells (see picture). Copyright
NOVEL TETRAZINES AND METHOD OF SYNTHESIZING THE SAME
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, (2013/10/22)
Provided herein, inter alia, are compositions and methods of synthesis and detection of tetrazines and diazonorcaradienes.
