140237-90-7

Upstream product

• 14225-52-6 2-ethyl-5-methyl-2,4-diphenyl-2,5-dihydro-thiazole 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 14229-62-0 S-1-methyl-2-oxo-2-phenylethyl thioacetate 
• 6084-17-9 2-chloro-1-phenylpropan-1-one 

Downstream Products

• 35676-50-7 1-Phenyl-β-<2-hydroxy-ethyl-mercapto>-propanon (1) 
• 14229-68-6 2-isopropyl-2,5-dimethyl-4-phenyl-2,5-dihydro-thiazole 
• 14229-70-0 5-methyl-2,4-diphenyl-2,5-dihydro-thiazole 
• 14229-69-7 2-(5-methyl-4-phenyl-2,5-dihydro-thiazol-2-yl)-phenol 
• 14229-66-4 2,2-diethyl-5-methyl-4-phenyl-2,5-dihydro-thiazole 
• 14229-67-5 2-ethyl-2,5-dimethyl-4-phenyl-2,5-dihydro-thiazole 
• 35676-52-9 1-Phenyl-β-<2-hydroxy-propyl-mercapto>-propanon (1) 
• 93-55-0 1-phenyl-propan-1-one 
• 14225-59-3 bis[1-benzoylethyl] disulfide 
• 14236-72-7 2-methylsulfanyl-1-phenyl-propan-1-one 
• 941568-95-2 (E)-S-1-methyl-2-oxo-2-phenylethyl thiocinnamate 
• 941568-94-1 S-1-methyl-2-oxo-2-phenylethyl thiophene-2-carbothioate 
• 14229-62-0 S-1-methyl-2-oxo-2-phenylethyl thioacetate 
• 67902-75-4 S-1-methyl-2-oxo-2-phenylethyl thiobenzoate 

Relevant academic research and scientific papers

α-Methylphenacyl thioesters as convenient thioacid precursors

α-Methylphenacyl (Mpa) thioesters are described as precursors of thioacids. Mpa thioesters are accessible via the condensation of carboxylic acids and phenacyl thiol, which is easily prepared without column chromatography. The Mpa thioesters are selectively deprotected by reduction with zinc dust in the presence of conventional thioacid protecting groups. In addition, the Mpa group exhibits orthogonal reactivity to the Boc group. These features are expected to facilitate the preparation of complex thioacids, including those in peptides.

On the Joint Reaction of Elemental Selenium with Gaseous Ammonia and Ethylenimine, respectively in the Presence of Ketones. Joint Reaction of Elementary Sulfur and Gaseous Ammonia with Ketones, 96.

Elemental sulfur reacts with ketones and gaseous ammonia at room temperature yielding thiazoline-3 in excellent yields.Under the same conditions elemental selenium does not react at all.Attempts using the known techniques which have been applied in improving the reactivity of slowly reacting ketones in thiazoline-3-synthesis have been unsuccessful (Exp.No. 1-17).The reaction of α-halogenketones with sodiumhydrogenselenide to synthesize α-hydroselenoketones gives only the original ketones and selenium in almost quantitative yields (No. 18-23).The same is observed with α-haloketones and sodium ore magnesium-diselenides (No. 24-45).The explanation of these unexpected results is the strong reducing power of the hydrogenselenide (No. 46-52).Even α-bromoketones with activated bromine (i.g. by phenyl groups) were reduced by sodiumhydrogensulfide giving red undefinite oils.However, α-chloroketones give α-mercaptoketones in excellent yields (No. 53-61).Hydrogenselenide reduces α-mercaptoketones to sulfur and ketones in the presence of triethylamine (No. 62-67).Also the transformation of α-selenocyanketones to α,α'-diketodiselenides by alkali or the oxidative hydrolysis of selenium-"BUNTE" salts does not work and gives elementary selenium only.Studies about the concomitant reaction of elementary selenium and ethylenimine on ketones were continued (No. 68-83). - Keywords: Dihydro-p-selenazine, α-Haloketones, Hydrogenselenide reducing Action, α-Mercaptoketones