14024-97-6Relevant articles and documents
Parsons,E.J.,Jennings,P.W.
, p. 3973 (1987)
Stiakaki, Maria-Aglaia D.,Christofides, Aristides
, p. 661 - 670 (1993)
Near-infrared light-mediated photoactivation of a platinum antitumor prodrug and simultaneous cellular apoptosis imaging by upconversion-luminescent nanoparticles
Min, Yuanzeng,Li, Jinming,Liu, Fang,Yeow, Edwin K. L.,Xing, Bengang
, p. 1012 - 1016 (2014)
Platinum-based drugs are among the most active antitumor reagents in clinical practice; their application is limited by side effects and drug resistance. A novel and personalized near-infrared (NIR) light-activated nanoplatform is obtained by combining a photoactivatable platinum(IV) prodrug and a caspase imaging peptide conjugated with silica-coated upconversion- luminescent nanoparticles (UCNPs) for the remote control of antitumor platinum prodrug activation, and simultaneously for real-time imaging of apoptosis induced by activated cytotoxicity. Upon NIR light illumination, the Pt IV prodrug complex is activated at the surface of the nanoparticle and active components are selectively released which display cytotoxicity against human ovarian carcinoma A2780 cells and its cisplatin-resistant variant A2780cis cells. More importantly, the caspases enzymes triggered by cytotoxicity would effectively cleave the probe peptide, thereby allowing the direct imaging of apoptosis in living cells. Platinum-based drugs: Near-infrared (NIR) light illumination of conjugates made of photoactive platinum(IV) prodrugs and upconversion-luminescent nanoparticles (UCNPs) is used for the remotely controlled activation of antitumor effects and for simultaneous initiation of apoptosis in the targeted tumor cells. The apoptosis-dependent caspase-3 enzyme offers the promising possibility of imaging apoptosis in real time. Copyright
trans-Dichlorotetrakis(pyridine)platinum(IV) Nitrate: a Classical Co-ordination Compound
Seddon, Kenneth R.,Turp, Janet E.,Constable, Edwin C.,Wernberg, Ole
, p. 293 - 296 (1987)
Claims that trans-dichlorotetrakis(pyridine)platinum(IV) nitrate forms a covalent hydrate when dissolved in water are shown to be in error; the observed acidity of the aqueous solution is due to the presence of a small amount of a strongly acidic impurity, and all of the observed physical and spectroscopic properties of the salt are simply interpreted in terms of classical co-ordination chemistry.
Hanks,T.W.,Jennings,P.W.
, p. 5023 (1987)
Platinum(iv)-azido monocarboxylato complexes are photocytotoxic under irradiation with visible light
Butler, Jennifer S.,Clarkson, Guy,Farrer, Nicola J.,Habtemariam, Abraha,Romero, Mar?a J.,Romero-Canelón, Isolda,Sadler, Peter J.,Salassa, Luca,Shaili, Evyenia,Woods, Julie A.
supporting information, p. 10593 - 10607 (2021/08/09)
Complexestrans,trans,trans-[Pt(N3)2(OH)(OCOR)(py)2] where py = pyridine and where OCOR = succinate (1); 4-oxo-4-propoxybutanoate (2) andN-methylisatoate (3) have been synthesized by derivation oftrans,trans,trans-[Pt(OH)2(N3)2(py)2] (4) and characterised by NMR and EPR spectroscopy, ESI-MS and X-ray crystallography. Irradiation of1-3with green (517 nm) light initiated photoreduction to Pt(ii) and release of the axial ligands at a 3-fold faster rate than for4. TD-DFT calculations showed dissociative transitions at longer wavelengths for1compared to4. Complexes1and2showed greater photocytotoxicity than4when irradiated with 420 nm light (A2780 cell line IC50values: 2.7 and 3.7 μM) and complex2was particularly active towards the cisplatin-resistant cell line A2780cis (IC503.7 μM). Unlike4, complexes1-3were phototoxic under green light irradiation (517 nm), with minimal toxicity in the dark. A pKa(H2O) of 5.13 for the free carboxylate group was determined for1, corresponding to an overall negative charge during biological experiments, which crucially, did not appear to impede cellular accumulation and photocytotoxicity.
Compound with antitumor activity, and preparation method and application thereof
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Paragraph 0094; 0095; 0096; 0100, (2017/12/28)
The invention provides a compound with antitumor activity, and a preparation method and application thereof, and relates to the technical field of chemical compounding drugs. The compound is of a structure shown as a formula (I) or (II). The stimuli-responsive self-assembly unimolecular compound with the antitumor activity is prepared through condensation reaction between hepatic-targeting water-soluble lactose and a platinum (IV) compound. The compound has the advantages that hepatic-targeting water-soluble lactose molecules are introduced, water-solubility of the platinum (IV) compound is improved, and hydrophilic-lyophobic balance is achieved, so that the self-assembly unimolecular platinum (IV) compound is formed, cytotoxicity of the platinum (IV) compound is reduced, a compounded tetravalence platinum prodrug has amphipathy, and accumulation degree of hepatoma cells can be increased; due to platinum, activation and release of the platinum compound are benefited under the conditions of external photostimulation or intracellular reduction, and accordingly, high antitumor activity is achieved.
