1402403-34-2Relevant academic research and scientific papers
Catalytic asymmetric synthesis of 2-alkyleneoxetanes through [2+2] annulation of allenoates with trifluoromethyl ketones
Zhao, Qian-Yi,Huang, Long,Wei, Yin,Shi, Min
, p. 1926 - 1932 (2012/09/22)
The first example of a β-isocupreidine (β-ICD)-catalyzed highly enantioselective [2+2] annulation of allenoates with trifluoromethyl ketones has been disclosed, allowing the synthesis of optically active 2-alkyleneoxetanes in moderate to good yields along with good to high enantioselectivities and high diastereoselectivities. Further transformations of the cycloadducts have been also disclosed to afford biologically interesting 6-trifluoromethyl-5,6- dihydropyran-2-ones and trifluoromethyl β-keto acids in good yields. Copyright
