1402411-90-8Relevant articles and documents
Using an electrical potential to reversibly switch surfaces between two states for dynamically controlling cell adhesion
Ng, Cheuk Chi Albert,Magenau, Astrid,Ngalim, Siti Hawa,Ciampi, Simone,Chockalingham, Muthukumar,Harper, Jason Brian,Gaus, Katharina,Gooding, John Justin
, p. 7706 - 7710 (2012)
Smart surfaces presenting both antifouling molecules with a charged functional group at their distal end, and molecules that are terminated by RGD peptides for cell adhesion, were fabricated and characterized (see picture). By applying potentials of +300 or -300 mV, the surfaces could be dynamically switched to make the peptide accessible or inaccessible to cells. Copyright
CONJUGATES COMPRISING PEPTIDE GROUPS AND METHODS RELATED THERETO
-
, (2017/08/08)
In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and at least two active agents. In preferred embodiments, the linker comprises a peptide sequence of a plurality of amino acids, and at least two of the active agents are covalently coupled to side chains of the amino acids. The antibody-drug conjugate may comprise a self-immolative group, preferably two-self-immolative groups. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
