1402572-07-9Relevant academic research and scientific papers
Reduced pulmonary surfactant interaction of daptomycin analogs via tryptophan replacement with alternative amino acids
He, Yong,Li, Jing,Yin, Nin,Herradura, Prudencio S.,Martel, Larry,Zhang, Yanzhi,Pearson, Andre L.,Kulkarni, Vidya,Mascio, Carmela,Howland, Karen,Silverman, Jared A.,Keith, Dennis D.,Metcalf, Chester A.
, p. 6248 - 6251 (2012)
Daptomycin was shown to interact in vitro with pulmonary surfactant leading to reduction of its antibacterial activity. We report herein the preparation and anti-staphylococcal activity of a series of daptomycin analogs with reduced pulmonary surfactant interaction by replacing tryptophan with various amino acids.
