1402652-87-2Relevant academic research and scientific papers
Bioinspired total synthesis of agelastatin A
Reyes, Jeremy Chris P.,Romo, Daniel
, p. 6870 - 6873 (2012/10/08)
A one-two punch: Two potentially biosynthetically relevant cyclizations of a keramadine analogue give agelastatin A (see scheme). A diastereoselective C-ring formation, which proceeds through a 5-exo-trig cyclization or a Nazarov cyclization of a red-colored N-acyliminium intermediate, generates the three contiguous stereocenters of the cyclopentane core. A silica gel assisted cyclization of a nagelamide J analogue gives agelastatin A. Copyright
