1402659-54-4Relevant articles and documents
Desmethyl macrolides: Synthesis and evaluation of 4,8-didesmethyl telithromycin
Wagh, Bharat,Paul, Tapas,Glassford, Ian,Debrosse, Charles,Klepacki, Dorota,Small, Meagan C.,MacKerell Jr., Alexander D.,Andrade, Rodrigo B.
, p. 1013 - 1018 (2012)
There is an urgent need for novel sources of antibiotics to address the incessant and inevitable onset of bacterial resistance. To this end, we have initiated a structure-based drug design program that features a desmethylation strategy (i.e., replacing m