1402723-42-5

Basic information

• Product Name: C₁₇H₂₆N₆O₃
• CAS NO: 1402723-42-5
• Molecular Weight: 362.432
• Mol File: 1402723-42-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₂₆N₆O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₂₆N₆O₃(1402723-42-5)
• EPA Substance Registry System: C₁₇H₂₆N₆O₃(1402723-42-5)

Safety Data

• Hazardous Substances Data: 1402723-42-5(Hazardous Substances Data)

Upstream product

• 2389-86-8 (2R)-2-acetamido-5-guanidino-pentanoate 
• 5241-58-7 L-Phenylalanine amide 

Relevant articles and documents

Opioid activity profiles of oversimplified peptides lacking in the protonable N-terminus

Recently, we described cyclopeptide opioid agonists containing the D-Trp-Phe sequence. To expand the scope of this atypical pharmacophore, we tested the activity profiles of the linear peptides Ac-Xaa-Phe-Yaa (Xaa = L/D-Trp, D-His/Lys/Arg; Yaa = H, GlyNH2). Ac-D-Trp-PheNH2 appeared to be the minimal binding sequence, while Ac-D-Trp-Phe-GlyNH 2 emerged as the first noncationizable short peptide (partial) agonist with high μ-opioid receptor affinity and selectivity. Conformational analysis suggested that 5 adopts in solution a β-turn conformation.