1402730-50-0Relevant articles and documents
Oxidative dearomative cross-dehydrogenative coupling of indoles with diverse C-H nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones
Jiang, Cheng-Shi,Liu, Xigong,Tang, Ying-De,Yan, Xue,Zhang, Hua
, (2020)
The oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles is developed. This process features a broad substrate scope with respect to both indoles and nucleophiles, affording structurally diverse 2,2-disubstituted indolin-3-ones in high yields (up to 99%). The oxidative dimerization and trimerization of indoles has also been demonstrated under the same conditions.
Indolyl substituted indole-3-ketone and synthesis method thereof
-
Paragraph 0066-0074, (2020/11/25)
The invention relates to an indolyl substituted indole-3-ketone and a synthesis method thereof. According to the method, an indole compound and an o-nitro alkyne compound are converted into the indolyl substituted indole-3-ketone in the argon atmosphere under a PPh3 reducing agent for the first time, and the prepared indole substituted indole-3-ketone is stable in molecular structure and excellentin chemical property. Reaction raw materials of the synthesis method are cheap and easy to obtain, and pretreatment is not needed; only acid and a reducing agent are used in the reaction without a metal catalyst so that raw materials are saved and the reaction cost is reduced; the whole reaction system is simple, reaction conditions are mild, reaction equipment is less, experimental operation issimple and convenient, and material sources are wide.